Trimethoprim-Sulfamethoxazole-Induced Hypoglycemia as a Cause of Altered Mental Status in an Elderly Patient

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Trimethoprim-sulfamethoxazole-induced hypoglycemia as a cause of altered mental status in an elderly patient.

Drug-induced hypoglycemia is an important consideration in the differential diagnosis of altered mental status, especially in the elderly patient. Symptoms can be insidious, causing subtle mental status changes. In addition to the well known hypoglycemic effects associated with treatment of diabetes mellitus, several commonly prescribed medications, such as thiazides, sulfonylureas, and. some a...

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Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis

BACKGROUND Methemoglobinemia due to the administration of sulfamethoxazole/trimethoprim has been documented in a series of case reports. However, all of these reports are on adult patients, and all patients received at least daily administration of sulfamethoxazole/trimethoprim for the treatment of active or suspected infection. CASE REPORT Herein we report the development of methemoglobinemia ...

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Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.

AIMS Pharmacokinetic studies suggest that trimethoprim (TMP) can inhibit the hepatic metabolism of phenytoin, but the clinical relevance of this is uncertain. We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin. METHODS We conducted a population-based, nested cas...

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Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis

Propylene glycol (PG) is used as a solvent in numerous medications, including trimethoprim/sulfamethoxazole (TMP/SMX) and lorazepam, and is metabolized in the liver to lactic acid. Cases of lactic acidosis related to PG toxicity have been described and always involved large doses of benzodiazepines and PG. We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX alone...

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ژورنال

عنوان ژورنال: The Journal of the American Board of Family Medicine

سال: 2000

ISSN: 1557-2625,1558-7118

DOI: 10.3122/15572625-13-3-211